Mandibular appliance modulates condylar growth through integrins.

  title={Mandibular appliance modulates condylar growth through integrins.},
  author={Mara R{\'u}bia Marques and Denise Hajjar and Kleber Gomes Franchini and Anselmo Sigari Moriscot and Marinilce Fagundes dos Santos},
  journal={Journal of dental research},
  volume={87 2},
Functional orthopedic therapy corrects growth discrepancies between the maxilla and mandible, possibly through postural changes in the musculature and modulation of the mandibular condylar cartilage growth. Using Wistar rats, we tested the hypothesis that chondrocytes respond to forces generated by a mandibular propulsor appliance by changes in gene expression, and that integrins are important mediators in this response. Immunohistochemical analyses demonstrated that the use of the appliance… CONTINUE READING
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