Mandible matrix necrosis in beagle dogs after 3 years of daily oral bisphosphonate treatment.

@article{Allen2008MandibleMN,
  title={Mandible matrix necrosis in beagle dogs after 3 years of daily oral bisphosphonate treatment.},
  author={Matthew R Allen and David B. Burr},
  journal={Journal of oral and maxillofacial surgery : official journal of the American Association of Oral and Maxillofacial Surgeons},
  year={2008},
  volume={66 5},
  pages={987-94}
}
PURPOSE An increasing number of reports have implicated bisphosphonates as contributing to osteonecrosis of the jaw. The goal of this study was to evaluate mandible necrosis in beagle dogs treated for 3 years with oral alendronate (ALN). MATERIALS AND METHODS Skeletally mature female beagles were treated daily for 3 years with oral doses of vehicle (VEH) or ALN (0.20 or 1.0 mg/kg/day). These doses approximate, on a mg/kg basis, those used for postmenopausal osteoporosis and Paget's disease… CONTINUE READING

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Drug for Bones Is Newly Linked to Jaw Disease

  • G. Kolata
  • 2006

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