Mandelonitrile beta-glucuronide: synthesis and characterization.

@article{Fenselau1977MandelonitrileBS,
  title={Mandelonitrile beta-glucuronide: synthesis and characterization.},
  author={Catherine Fenselau and S L Pallante and R P Batzinger and Walter R. Benson and R P Barron and E B Sheinin and M Maienthal},
  journal={Science},
  year={1977},
  volume={198 4317},
  pages={625-7}
}
Mandelonitrile beta-glucuronide, the compound patented as Laetrile, has been synthesized from rabbit liver uridine diphosphate-glucuronosyl transferase immobilized on beaded sepharose, has been analyzed by thin-layer chromatography, nuclear magnetic resonance, and gas chromatography-mass spectrometry, and has been tested for cytotoxicity and mutagenic activity with Salmonella typhimurium strains TA 98 and TA 100. Several commercial laetrile preparations contained no glucuronide; they contained… CONTINUE READING