Managing toxic shock syndrome with antibiotics

@article{Annane2004ManagingTS,
  title={Managing toxic shock syndrome with antibiotics},
  author={Djillali Annane and Bernard Clair and J{\'e}r{\^o}me Salomon},
  journal={Expert Opinion on Pharmacotherapy},
  year={2004},
  volume={5},
  pages={1701 - 1710}
}
Toxic shock syndrome (TSS) is a serious disorder with a worldwide prevalence of ∼ 3/100,000 persons. TSS is mainly caused by Streptococcus pyogenes or Staphylococcus aureus. Thus, β-lactam and lincosamides, such as clindamycin, are the first-line drugs. Yet, the mortality rate remains unacceptably high; highlighting the role of bacterial toxin-mediated activation of the inflammatory cascade in TSS pathogenesis. Further strategies should be targeted towards interfering with the interaction… Expand
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扁桃周囲膿瘍によるtoxic shock syndrome例
TLDR
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TLDR
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Toxic shock syndrome.
Toxic shock syndrome is outlined, paying particular attention to the important role of nurses in its diagnosis and early management
Toll-like receptor 2 ligands on the staphylococcal cell wall downregulate superantigen-induced T cell activation and prevent toxic shock syndrome
TLDR
It is shown that the human interleukin-2 response to staphylococcal superantigens is inhibited by the simultaneous presence of bacteria, and a downregulatory effect is the result of peptidoglycan-embedded molecules binding to Toll-like receptor 2 and inducing interleucin-10 production and apoptosis of antigen-presenting cells. Expand
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References

SHOWING 1-10 OF 78 REFERENCES
Streptococcal toxic-shock syndrome: spectrum of disease, pathogenesis, and new concepts in treatment.
  • D. Stevens
  • Biology, Medicine
  • Emerging infectious diseases
  • 1995
TLDR
The clinical and demographic features of streptococcal bacteremia, myositis, and necrotizing fasciitis are presented and compared to those of strePTococcal toxic-shock syndrome and current concepts in the pathogenesis of invasive streptitiscal infection are presented. Expand
A new therapeutic strategy for streptococcal toxic shock syndrome: a key target for cytokines.
TLDR
Direct hemoperfusion with polymyxin B-immobilized fiber and continuous hemodiafiltration coupled with plasma exchange for simultaneous removal of several mediators of the inflammatory cascade improved outcome and lessened the aggressive clinical course and prolonged survival in patients with STSS. Expand
TOXIC-SHOCK SYNDROME ASSOCIATED WITH PHAGE-GROUP-I STAPHYLOCOCCI
TLDR
One patient died, one had gangrene of the toes, and all have had fine desquamation of affected skin and peeling of palms and soles during convalescence. Expand
Group B Streptococcal Necrotizing Fasciitis and Toxic Shock-Like Syndrome: A Case Report and Review of the Literature
TLDR
Since the mechanism of GBS toxic shock may be similar to Group A Streptococcus, intravenous immunoglobulin should be considered as an adjunct to clindamycin-based antibiotic therapy. Expand
[Special features of intensive care of toxic shock syndrome. Review and case report of a TSST-1 associated toxic-shock syndrome with adult respiratory distress syndrome and multiple organ failure from a staphylococcal panaritium].
TLDR
The signs and symptoms of toxic-shock-syndrome should be recognised early to permit successful therapy and possible complications including ARDS and myocardial failure require a thorough understanding of its underlying pathophysiology to ensure appropriate intensive-care treatment. Expand
Severe group a streptococcal infection and streptococcal toxic shock syndrome
TLDR
Management of STSS requires volume resuscitation, vasopressor/inotrope infusion, antibiotic therapy and supportive care in an intensive care unit, usually including mechanical ventilation, andIntravenous immunoglobulin infusion has been recommended. Expand
Defining the group A streptococcal toxic shock syndrome. Rationale and consensus definition. The Working Group on Severe Streptococcal Infections.
TLDR
Group A streptococcal infections characterized by signs including shock, multi—organ system involvement, and rapidly progressive, destructive soft-tissue infection (necrotizing fasciitis) even though most patients received appropriate antimicrobial therapy, supportive care, and, where necessary, surgical debridement. Expand
Major Outbreak of Toxic Shock-Like Syndrome Caused by Streptococcus mitis
TLDR
This TSLS outbreak in southeastern China was caused by a toxigenic clone of S. mitis, and an apparently novel toxin may explain the unusual virulence of this organism. Expand
Toxic shock syndrome toxin 1 as an inducer of human tumor necrosis factors and gamma interferon
TLDR
TSST-1, which is also known as an inducer of IL-1 and IL-2, stimulates the production of endogenous mediators that could play a role in the physiopathological processes of toxic shock syndrome (TSS). Expand
[Staphylococcal and streptococcal pediatric toxic syndrome from 1998 to 2000. Data from the National Center for Staphylococcal Toxemia].
TLDR
Investigation of the clinical and microbial settings of staphylococcal and streptococcal toxemia in pediatric patients found evidence of skin infections as the source of the majorities of stAPHylococCal toxic shock syndrome and staphlyococcal scarlet fever as described for nosocomial suppurative infections. Expand
...
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5
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