Managing the late complications of Parkinson's disease.

  title={Managing the late complications of Parkinson's disease.},
  author={Cheryl H. Waters},
  volume={49 1 Suppl 1},
Most patients with Parkinson's disease (PD) receiving chronic levodopa therapy eventually manifest one or more motor response complications, including "wearing-off" phenomena and "on-off" phenomena. Additionally, as the disease progresses, motor, neurologic, and neuropsychiatric complications increase and may include freezing spells, falls, dementia, depression, and psychosis. The management of patients with advanced PD presents a special clinical challenge because patients may experience an… CONTINUE READING


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