Managing skin damage induced by doxorubicin hydrochloride and daunorubicin hydrochloride.

@article{Cox1984ManagingSD,
  title={Managing skin damage induced by doxorubicin hydrochloride and daunorubicin hydrochloride.},
  author={Richard F. B. Cox},
  journal={American journal of hospital pharmacy},
  year={1984},
  volume={41 11},
  pages={
          2410-4
        }
}
The pathophysiology and mechanisms of toxicity of anthracycline-induced skin damage are reviewed, and the various available therapeutic interventions are discussed. Skin ulcers caused by the vesicant antineoplastic agents doxorubicin hydrochloride and daunorubicin hydrochloride begin slowly, and the extent of the tissue damage produced is often underestimated. Within a week, untreated infiltrations of these agents can advance to serious indurations and ulcerations, causing extensive damage to… CONTINUE READING

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