The medical record department plays an important role in supplying information for a variety of hospital functions. That role traditionally includes compiling demographic data and diagnosis and procedure indexes. The medical record professional is well-qualified to offer expanded informational services encompassing the management of research studies, and thus contribute to the advancement of medicine. This article describes how Cleveland Clinic Foundation's medical record department manages retrospective studies. The authors offer suggestions for other medical record professionals interested in expanding their roles in clinical research.