Managing hirsutism in gynaecological practice

@article{Conn1998ManagingHI,
  title={Managing hirsutism in gynaecological practice},
  author={Jennifer J. Conn and Howard S. Jacobs},
  journal={BJOG: An International Journal of Obstetrics \& Gynaecology},
  year={1998},
  volume={105}
}
  • J. Conn, H. Jacobs
  • Published 1998
  • Medicine
  • BJOG: An International Journal of Obstetrics & Gynaecology
Hirsutism results from an excess of circulating androgens, an increase in the sensitivity of hair follicles to normal androgen concentrations or a combination of these factor^^,^. In women, androgens are secreted both by the ovaries and by the adrenal glands and also arise from peripheral conversion of androstenedione and dehydroepiandrosterone. The major androgens of biological importance are testosterone and its metabolite dihydrotosterone; this metabolite is the more potent and is produced… Expand
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Antiandrogens (androgen receptor blockers) are the best medical treatment of cutaneous hyperandrogenism. Expand
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HE PREDOMINANT emphasis in the study of hormones in post-menopausal women has been accorded to estrogens and progestins, with lesser attention being given to androgens and the issue of androgenExpand
Peripheral androgen blockade versus glandular androgen suppression in the treatment of hirsutism
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The data suggest that serum androgens are not helpful in assessing response to the treatment of hirsutism and that despite normal androgen levels, only modest clinical improvement may be expected with dexamethasone treatment. Expand
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It is concluded that the combination of 30 μg ethinyl oestradiol (EE2) and 150 μg desogestrel (Marvelon) is a suitable oral contraceptive for the treatment of hirsute women. Expand
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Investigation of the use of one superactive agonistic GnRH analog, nafarelin, in the treatment of hirsutism found that serum gonadotropin, testosterone, free testosterone, and androstenedione concentrationsdecreased significantly during treatment. Expand
Treatment of hirsutism with a gonadotropin-releasing hormone agonist (nafarelin).
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By suppressing ovarian androgen production, nafarelin may be useful for the treatment of hirsutism associated with either increased ovarian androgens production or increased sensitivity of the hair follicle to normal concentrations of circulating androgens. Expand
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Considering the good clinical results and the avoidance of any hepatic effect, this association should be taken into account in the treatment of hirsutism, especially in case of oral estrogen intolerance. Expand
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Goserelin, a long-acting GnRH agonist, is an effective treatment for ovarian hyperandrogenism by estrogens and suppression of gonadotropins, rather than the increase in SHBG, appears to be of primary significance in the alleviation of ovarian hyper androgenismBy estrogens. Expand
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Treatment of hirsutism by an association of oral cyproterone acetate and transdermal 17β‐estradiol
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Considering the good clinical results and the avoidance of any hepatic effect, this association should be taken into account in the treatment of hirsutism, especially in case of oral estrogen intolerance. Expand
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