Managing delayed or altered puberty in boys

@article{Pitteloud2012ManagingDO,
  title={Managing delayed or altered puberty in boys},
  author={Nelly Pitteloud},
  journal={BMJ : British Medical Journal},
  year={2012},
  volume={345}
}
  • N. Pitteloud
  • Published 2012
  • Medicine
  • BMJ : British Medical Journal
Early identification and treatment, both medical and psychological, is key 

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References

SHOWING 1-9 OF 9 REFERENCES
It's not all about the testes: medical issues in Klinefelter patients.
  • R. Sokol
  • Medicine
  • Fertility and sterility
  • 2012
Important medical conditions associated with Klinefelter syndrome (KS) are categorized as: 1) motor, cognitive, and behavioral dysfunction; 2) tumors; 3) vascular disease; and 4) endocrine/metabolicExpand
Treating hypogonadism in younger males
TLDR
Treatment options for hypogonadism and induction of puberty have expanded and can be individualized based on patient preference, side effect profile, and a number of other parameters. Expand
Genetic basis and variable phenotypic expression of Kallmann syndrome: towards a unifying theory
TLDR
Oligogenic and complex genetic-environmental interactions have now been identified, with physiological and environmental factors interacting in genetically susceptible individuals to alter the clinical course and phenotype and potentially link IHH to ancient evolutionary pressures on the ancestral human genome. Expand
Neonatal gonadotropin therapy in male congenital hypogonadotropic hypogonadism
TLDR
Encouraging results of neonatal therapy, together with a few reports of prepubertal treatment, support the use of this novel therapeutic strategy aimed at improving sexual and reproductive functions in adulthood in male patients with CHH. Expand
The physiology and timing of male puberty
TLDR
Evaluation of Tanner stage and especially assessment of testicular volume should both be used in epidemiological studies and it is speculated that the association between fat mass and pubertal timing may be nonlinear and recent studies may indicate a small decline in age in boys. Expand
Secondary Sexual Characteristics in Boys: Data From the Pediatric Research in Office Settings Network
TLDR
Observed mean ages of beginning genital and pubic hair growth and early testicular volumes were 6 months to 2 years earlier than in past studies, depending on the characteristic and race/ethnicity. Expand
Clinical practice. Delayed puberty.
From the Division of Endocrinology, the Hospital for Sick Children, and the Departments of Pediatrics and Physiology, University of Toronto — both in Toronto (M.R.P.); and the Centre forExpand
Olfactory phenotypic spectrum in idiopathic hypogonadotropic hypogonadism: pathophysiological and genetic implications.
TLDR
IHH subjects display a broad spectrum of olfactory function, with a significant hyposmic phenotype in nearly one third of subjects, suggesting a pathophysiological overlap between Kallmann syndrome and normosmic IHH. Expand
Klinefelter syndrome : the forgotten syndrome : basic and clinical questions posed to an international group of scientists
  • Acta Paediatrica
  • 2011