Managing chronic inflammation in the aging diabetic patient with CKD by diet or sevelamer carbonate: a modern paradigm shift.

@article{Vlassara2012ManagingCI,
  title={Managing chronic inflammation in the aging diabetic patient with CKD by diet or sevelamer carbonate: a modern paradigm shift.},
  author={Helen Vlassara and Weijing Cai and Xiao-chun Chen and Eleazar Jim{\'e}nez Serrano and Mysore S. Shobha and Jaime Uribarri and Mark Woodward and Gary E. Striker},
  journal={The journals of gerontology. Series A, Biological sciences and medical sciences},
  year={2012},
  volume={67 12},
  pages={1410-6}
}
The maintenance of normal metabolism and body defenses depends on the balance between cellular antioxidant and anti-inflammatory factors. This balance can be disrupted by agents/mechanisms in the extracellular milieu that induce excess reactive oxygen species (ROS) and inflammation. Cytopathic advanced glycation endproducts, present in ever increasing amounts in the modern diet, are one of the major environmental factors that cause excess ROS and/or inflammation at all ages and induce… CONTINUE READING
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