Managing cardiovascular and renal risk: the potential of direct renin inhibition.

  title={Managing cardiovascular and renal risk: the potential of direct renin inhibition.},
  author={Peter S Sever and Alan H. Gradman and Michel Azizi},
  journal={Journal of the renin-angiotensin-aldosterone system : JRAAS},
  volume={10 2},
Aliskiren is the first direct renin inhibitor for the treatment of hypertension. Clinical experience from studies in over 14,000 patients has shown that aliskiren, alone or in combination with other antihypertensive therapies, provides effective blood pressure lowering with a good safety and tolerability profile.The ultimate aim of antihypertensive therapy, however, is to reduce the risk of adverse cardiovascular and renal outcomes.The effect of aliskiren on surrogate markers of organ damage… CONTINUE READING

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