Managing Cutaneous Manifestations of Hyperandrogenic Disorders

@article{Wiegratz2002ManagingCM,
  title={Managing Cutaneous Manifestations of Hyperandrogenic Disorders},
  author={Inka Wiegratz and Herbert Kuhl},
  journal={Treatments in Endocrinology},
  year={2002},
  volume={1},
  pages={373-386}
}
Cutaneous manifestations of hyperandrogenic disorders (acne, seborrhea, hirsutism and androgenetic alopecia) can be caused by elevated levels of free testosterone or androgen precursors. In women with normal serum levels of testosterone or androgen precursors, enhanced local conversion to testosterone, or to the more potent androgen dihydrotestosterone, may lead to increased androgen activity in the pilosebaceous unit. Large individual variations in the response to normal or elevated androgens… 

Androgenetic alopecia and current methods of treatment.

By far the most promising approaches to the treatment of baldness in men are drug therapies, such as topical minoxidil and finasteride administered systemically.

Skin microbiota in women of reproductive age in norm and androgen-dependent dermatoses

The investigation of the skin microbial component in androgen-dependent dermatoses, such as acne and seborrheic dermatitis, will contribute to understanding the pathogenic mechanisms of these diseases and to developing effective methods of therapy.

Polymorphic CAG repeat numbers in the androgen receptor gene of female pattern hair loss patients

The efficacy of this medicine in each FPHL patient cannot be predicted by the CAG repeat numbers in the AR gene, and no statistical significance was detected among the four groups classified on the basis of the efficacy of finasteride.

Metformin Treatment is Effective in Obese Teenage Girls With PCOS

Metformin has favorable effects on ovulation in moderately obese adolescents with PCOS, and may well be a more appropriate treatment than estrogen and progestin in these patients, not only promoting ovulation but relieving symptoms of hyperandrogenism.

Clinical and histological challenge in the differential diagnosis of diffuse alopecia: female androgenetic alopecia, telogen effluvium and alopecia areata - Part II*

In this second part of the study, chronic telogen effluvium and diffuse alopecia areata are discussed in detail, including clinical, dermoscopic and histological aspects.

[Meibomian glands : part III. Dysfunction - argument for a discrete disease entity and as an important cause of dry eye].

  • E. KnopN. Knop F. Schirra
  • Medicine
    Der Ophthalmologe : Zeitschrift der Deutschen Ophthalmologischen Gesellschaft
  • 2009
Careful investigation of the eyelids and lid margins with eversion, if necessary, should therefore be performed in every case of a wetting defect, notably before fitting contact lenses.

Hormonal therapies and meningioma: is there a link?

Ovulationshemmer bei Risikogruppen

The hormonal methods and non-hormonal alternatives available for contraception are elucidated according to existing lesions and risk factors and the advantages and disadvantages are discussed.

References

SHOWING 1-10 OF 69 REFERENCES

Inhibition of skin 5α-reductase by oral contraceptive progestins in vitro

Data demonstrate that the progestins norgestimate and dienogest in particular combined 5α-reductase inhibition with minimal androgenic potential and might help in the treatment of clinical hyperandrogeny in women.

Androgen conjugates: physiology and clinical significance.

Serum levels of testosterone, androstenedione, and dehydroepiandrosterone sulfate (DHEAS) have been used as markers of overproduction of androgens or their precursors and are often elevated in hirsute women, but it has been more difficult to find markers of skin sensitivity to androgens.

Androgenetic alopecia: an autosomal dominant disorder.

  • W. Bergfeld
  • Medicine, Biology
    The American journal of medicine
  • 1995

Hirsutism in women. Effective therapy that is safe for long-term use.

Combination therapies, specifically oral contraceptives along with antiandrogen agents, are the most effective and addition of low-dose GnRH agonist therapy prolongs remission of hirsutism and most methods produce improvement within 6 months, with continued improvement at 12 months.

Role of hormones in pilosebaceous unit development.

The biological and endocrinological basis of PSU development and the hormonal treatment of the PSU disorders hirsutism, acne vulgaris, and pattern alopecia are reviewed.

Increased 5α-reductase activity in idiopathic hirsutism*†

The effect of metformin on hirsutism in polycystic ovary syndrome.

It is demonstrated that metformin treatment in a group of women with PCOS results in a clinically and statistically significant improvement in hair growth compared with placebo.
...