Management of worsening multiple sclerosis with mitoxantrone: a review.

  title={Management of worsening multiple sclerosis with mitoxantrone: a review.},
  author={Edward J. Fox},
  journal={Clinical therapeutics},
  volume={28 4},
BACKGROUND Mitoxantrone, an intravenously administered immunosuppressant that inhibits T-cell, B-cell, and macrophage proliferation, is indicated for reducing neurologic disability and relapse frequency in patients with secondary progressive multiple sclerosis (SPMS), progressive relapsing MS, or worsening relapsing-remitting MS (RRMS). OBJECTIVE This article reviews the pathogenesis and natural history of MS and examines the available treatment options for patients with RRMS, worsening RRMS… CONTINUE READING
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