Management of the syndrome of inappropriate antidiuretic hormone secretion in small cell lung cancer.

@article{Hainsworth1983ManagementOT,
  title={Management of the syndrome of inappropriate antidiuretic hormone secretion in small cell lung cancer.},
  author={John D Hainsworth and R Chad Workman and Frank Anthony Greco},
  journal={Cancer},
  year={1983},
  volume={51 1},
  pages={161-5}
}
From 1976 to 1980, 18 of the 250 patients (7%) seen with small cell carcinoma of the lung had clinically evident inappropriate secretion of antidiuretic hormone (ADH). Hyponatremia was usually severe (116 +/- 7 meq/l), and eight patients showed symptoms of water intoxication at the time of diagnosis. Of the eight patients who had plasma ADH measured at diagnosis, seven had elevated values (mean 52.0, range 16.1 - greater than 250 pg/ml). Intensive combination chemotherapy produced objective… CONTINUE READING