Management of side effects of sirolimus therapy.

@article{Stallone2009ManagementOS,
  title={Management of side effects of sirolimus therapy.},
  author={Giovanni Stallone and Barbara Infante and Giuseppe Grandaliano and Loreto Gesualdo},
  journal={Transplantation},
  year={2009},
  volume={87 8 Suppl},
  pages={S23-6}
}
Sirolimus (SRL) has been shown to improve long-term graft survival in several calcineurin inhibitor avoidance/minimization protocols. Although SRL has been suggested to reduce the progression of chronic renal graft damage and to prevent the development of neoplasia, two of the most prominent challenges in the field of transplantation, its use is significantly limited by an extremely high incidence of side effects. Some of the side effects are directly linked to the antiproliferative action of… CONTINUE READING