Management of paraneoplastic neurological syndromes: report of an EFNS Task Force

@article{Vedeler2006ManagementOP,
  title={Management of paraneoplastic neurological syndromes: report of an EFNS Task Force},
  author={Christian A Vedeler and J. C. Antoine and Bruno Giometto and Francesc Graus and Wolfgang Grisold and Ian K. Hart and J{\'e}r{\^o}me Honnorat and Peter A. E. Sillevis Smitt and J J Verschuuren and Raymond Voltz},
  journal={European Journal of Neurology},
  year={2006},
  volume={13}
}
Paraneoplastic neurological syndromes (PNS) are remote effects of cancer on the nervous system. An overview of the management of classical PNS, i.e. paraneoplastic limbic encephalitis, subacute sensory neuronopathy, paraneoplastic cerebellar degeneration, paraneoplastic opsoclonus‐myoclonus, Lambert–Eaton myasthenic syndrome and paraneoplastic peripheral nerve hyperexcitability is given. Myasthenia gravis and paraproteinemic neuropathies are not included in this report. No evidence‐based… 
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TLDR
LE was the first historically identified CNS PNS, and similarities between other temporal lobe diseases such as herpes encephalitis have been elucidated, and several autoantibodies have been described in association with LE.
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  • S. Alavi
  • Medicine
    Iranian journal of child neurology
  • 2013
TLDR
This study reviews the presenting symptoms, immunology, and management options for paraneoplastic syndromes, focusing on those most commonly reported in children.
PARANEOPLASTIC NEUROLOGICAL SYNDROMES DIAGNOSIS AND TREATMENT
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TLDR
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TLDR
There is no class I or II evidence for PNS therapy except for the syndromes that affect the neuromuscular junction (paraneoplastic myasthenia gravis, Lambert-Eaton myasthensic syndrome, and neuromyotonia).
Update on paraneoplastic neurological syndromes
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There is increasing recognition of an extensive array of PNS and of several paraneoplastic antibodies as biological markers of these disorders and basic immunological studies support the pathogenic role of some of these antibodies.
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