Management of opioid-induced bowel dysfunction in cancer patients

  title={Management of opioid-induced bowel dysfunction in cancer patients},
  author={Antonio Cesar Tamayo and Paola Andrea D{\'i}az-Zuluaga},
  journal={Supportive Care in Cancer},
The gastrointestinal (GI) effects of morphine and other opioids may result in opioid-induced bowel dysfunction (OBD) and the need for treatment. Although OBD is very common in morphine-treated patients, it is usually under-diagnosed. Opioids deliver their GI effect through central and peripheral mechanisms. Laxatives are the pharmaceuticals prescribed most in this area. Prokinetics as well as cholinergic agonists have been used satisfactorily. One-third of patients with OBD have to be treated… CONTINUE READING


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