Management of metastatic renal cell carcinoma patients with poor-risk features: current status and future perspectives

@article{Santoni2013ManagementOM,
  title={Management of metastatic renal cell carcinoma patients with poor-risk features: current status and future perspectives},
  author={Matteo Santoni and Michele De Tursi and Alessandra Felici and Giovanni Lo Re and Riccardo Ricotta and Enzo Maria Ruggeri and Roberto Sabbatini and Daniele Santini and Vanja Vaccaro and Michele Milella},
  journal={Expert Review of Anticancer Therapy},
  year={2013},
  volume={13},
  pages={697 - 709}
}
With seven agents approved for renal cell carcinoma within the past few years, there has undoubtedly been progress in treating this disease. However, patients with poor-risk features remain a challenging and difficult-to-treat population, with the mTOR inhibitor, temsirolimus, the only agent approved in the first-line setting. Phase III trial data are still lacking VEGF-pathway inhibitors in patients with poor prognostic features. Poor-risk patients need to be considered as a heterogeneous… 
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