Management of hypothyroidism in adults

@article{Vaidya2008ManagementOH,
  title={Management of hypothyroidism in adults},
  author={Bijay Vaidya and Simon H S Pearce},
  journal={BMJ : British Medical Journal},
  year={2008},
  volume={337}
}
Hypothyroidism is one of the commonest chronic disorders in Western populations. In the United Kingdom, the annual incidence of primary hypothyroidism in women is 3.5 per 1000 and in men 0.6 per 1000.1 During 2006 12 million prescriptions for levothyroxine (50 μg or 100 μg tablets) were dispensed in England, equivalent to about 1.6 million people taking long term thyroid replacement therapy, about 3% of the population.2 The management of hypothyroidism is generally considered straightforward… 
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83 Citations

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A snapshot of the range of accepted clinical practice in this common condition is formed, for a 53-year-old woman with fatigue and difficulty losing weight, who has a serum TSH of 6.8 mU/l and strongly positive thyroid peroxidase antibodies, 95% of respondents would treat with levothyroxine.

Hypothyroidism: Investigation and management

The aetiology, clinical features, investigation and management of hypothyroidism is outlined, with the significance of elevated TSH associated with thyroid hormones within normal range is controversial; thyroxine replacement may be beneficial in some cases.

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The Thyroid Registry: Clinical and Hormonal Characteristics of Adult Indian Patients with Hypothyroidism

Most of the patients as observed in this registry received treatment with levothyroxine based on TSH levels alone, thus highlighting the need for awareness and scientific education among clinicians in India.

TSH levels and risk of miscarriage in women on long-term levothyroxine: a community-based study.

The majority of levothyroxine-treated women have early gestational TSH levels above the recommended targets with a strong risk of miscarriage at levels exceeding 4.5 mU/L, and there is an urgent need to improve the adequacy of thyroid hormone replacement in early pregnancy.

EFFECT OF YOGA ON SUBCLINICAL HYPOTHYROIDISM : A CASE REPORT

It is suggested that yoga can be an effective adjunct therapy in thyroid conditions and further studies in larger samples are needed to confirm these findings and to better understand the mechanisms behind such beneficial effects in patients of thyroid disorders.

Drug Interactions with Levothyroxine Therapy in Patients with Hypothyroidism: Observational Study in General Practice

Clinicians should carefully consider adjusting levothyroxine therapy in presence of concomitant drugs, such as proton-pump inhibitors, which may reduce lev Timothyroxine bioavailability.

Hypothyroidism after a cancer diagnosis: etiology, diagnosis, complications, and management.

Thyroid dysfunction can be easily overlooked in cancer patients because of the complexity of cancer's clinical picture, particularly in the pediatric population and the management of both hypothyroidism and the malignancy.

Respiratory Manifestations of Hypothyroidism: A Systematic Review.

Mechanistic data linking hypothyroidism and respiratory function are at best limited and this area of research is open for retesting hypotheses, using appropriate study designs and methods.
...

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