Management of hyperleukocytosis and prevention of tumor lysis syndrome with low-dose prednisone continuous infusion in children with acute lymphoblastic leukemia.

@article{Ozdemir2009ManagementOH,
  title={Management of hyperleukocytosis and prevention of tumor lysis syndrome with low-dose prednisone continuous infusion in children with acute lymphoblastic leukemia.},
  author={Mehmet Akif Ozdemir and Musa Karakukcu and Turkan Patiroğlu and Yasemin Altuner Torun and Mehmet R Kose},
  journal={Acta haematologica},
  year={2009},
  volume={121 1},
  pages={
          56-62
        }
}
INTRODUCTION The standard management of childhood acute lymphoblastic leukemia with hyperleukocytosis is unclear and its treatment has focused on prompt leukocytoreduction. Cytoreductive therapies have been used for the prevention of tumor lysis syndrome, but the outcomes have been variable and their benefits have not been proven in controlled clinical trials. This condition needs further investigation to develop effective therapeutic strategies. METHODS In the present prospective trial, 15… CONTINUE READING