Management of hepatocellular carcinoma

  title={Management of hepatocellular carcinoma},
  author={Jordi Bruix and Morris Sherman},
The incidence of hepatocellular carcinoma (HCC) has increased worldwide and is now the 5th most frequent cancer representing approximately 5% of all cancers worldwide. More than 500,000 new cases are diagnosed per year and it is the third cause of cancer-related death and the first cause of death in patients with cirrhosis [1]. The incidence of HCC has major geographical differences, but most patients diagnosed with HCC have underlying cirrhosis. The highest risk is observed in cirrhosis from… 

Neoadjuvant Chemotherapy for Hepatocellular Carcinoma

Liver cirrhosis, especially after chronic infection with hepatitis B or C virus, remains the main risk factor that predisposes to the development of HCC, although rarely can HCC develop in a patient without cirrhotic liver.

Risk of recurrence in hepatitis B-related hepatocellular carcinoma: impact of viral load in late recurrence.

  • Y. Hoshida
  • Medicine, Biology
    Journal of hepatology
  • 2009

Autoimmune Hepatitis, Cirrhosis, and Hepatocellular Carcinoma (HCC)

The cost-effectiveness largely depends on the outcomes of treatment, and so studies like the Chinese program, which lacked access to OLT, are not necessarily relevant to other centers where transplantation is the first-line treatment for patients with cirrhosis and a small tumour.

Prevention of hepatitis C virus infection and liver cancer.

  • E. LimJ. Torresi
  • Medicine, Biology
    Recent results in cancer research. Fortschritte der Krebsforschung. Progres dans les recherches sur le cancer
  • 2014
It is imperative to provide antiviral therapy to infected individuals prior to the development of established cirrhosis in order to reduce the risk of subsequent HCC, as the successful eradication of HCV is associated with clinical and histological improvement as well as a greatly reduced risk ofsequent HCC development.

Surveillance for hepatocellular carcinoma: can we focus on the mission?

  • F. KanwalH. El‐SeragDavid B Ross
  • Medicine
    Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association
  • 2015

Is family history of liver cancer a risk factor for hepatocellular carcinoma?

Modern diagnosis of hepatocellular carcinoma: Utilization of liver biopsy and genomic markers.

  • J. Marrero
  • Medicine, Biology
    Journal of hepatology
  • 2009

Chronic hepatitis B and hepatocellular carcinoma.

Hepatocarcinoma: from pathogenic mechanisms to target therapy

A diagnostic approach to HCC has been developed incorporating serology, cytohistology, and radiological characteristics, and a precise staging of the disease may help decide on prognosis as well as choice of therapy with the greatest survival potential.



Hepatocellular carcinoma in primary biliary cirrhosis: similar incidence to that in hepatitis C virus–related cirrhosis

The risk for HCC in Patients with late stages of PBC is similar to that in patients with HCV-related cirrhosis, and the probability for developing HCC was significantly higher in patientsWith HCv-related Cirrhosis than in PBC patients overall, but was similar in patientswith HCV -related cir rhosis and in patients in stages III and IV.

Interferon Therapy Reduces the Risk for Hepatocellular Carcinoma: National Surveillance Program of Cirrhotic and Noncirrhotic Patients with Chronic Hepatitis C in Japan

An analysis of the effect of interferon therapy on the incidence and prevention of hepatocellular carcinoma in patients with chronic hepatitis C who have undergone liver biopsy at one of eight participating institutions supported by the Japan Ministry of Health and Welfare.

Hepatocellular carcinoma in Austria: aetiological and clinical characteristics at presentation

The dominant contribution of HCV infection and chronic alcohol abuse as the underlying aetiology is documented in this large single‐centre series of HCC.

Primary liver cancer: worldwide incidence and trends.

The incidence of primary liver cancer is increasing in several developed countries, including the United States, and the increase will likely continue for some decades, the trend is a result of a cohort effect related to infection with hepatitis B and C viruses.

Hepatocellular carcinoma in HIV-infected patients: epidemiological features, clinical presentation and outcome

HCC in HIV-infected patients is mainly associated with underlying chronic hepatitis C and has a more aggressive clinical course, so preventative strategies (including the treatment of hepatitis C) should be implemented in the management of HIV/HCV-coinfected patients.

Cirrhosis and hepatocellular carcinoma in HIV-infected veterans with and without the hepatitis C virus: a cohort study, 1992-2001.

Hepatitis C virus coinfection dramatically promotes the development of HCC and of cirrhosis, and is especially associated with Cirrhosis in the highly active antiretroviral therapy era.

Hepatocellular carcinoma in Italian patients with cirrhosis.

In the West, as in Asia, patients with cirrhosis of the liver are at substantial risk for hepatocellular carcinoma, with a yearly incidence rate of 3 percent, and the screening program did not appreciably increase the rate of detection of potentially curable tumors.

Familial risk of hepatocellular carcinoma among chronic hepatitis B carriers and their relatives.

First-degree relatives of patients with HBV-related HCC appear to be at increased risk of HCC and should be considered in the formulation of H CC-screening programs.