Management of heparin resistance during cardiopulmonary bypass: the effect of five different anticoagulation strategies on hemostatic activation.

@article{Koster2003ManagementOH,
  title={Management of heparin resistance during cardiopulmonary bypass: the effect of five different anticoagulation strategies on hemostatic activation.},
  author={Andreas Koster and Thomas Fischer and Marcus Gruendel and Andreas Mappes and Wolfgang Michael Kuebler and Matthias Bauer and Herman Kuppe},
  journal={Journal of cardiothoracic and vascular anesthesia},
  year={2003},
  volume={17 2},
  pages={171-5}
}
OBJECTIVE Attenuation of hemostatic activation is a central goal during CPB. However, this poses a problem in patients insensitive to heparin. The present investigation was performed to assess different strategies of managing patients with heparin resistance during CPB. DESIGN A randomized, prospective clinical investigation. SETTING A major European heart center. PARTICIPANTS Five groups with 20 patients each were investigated. INTERVENTIONS The groups were handled as follows: (1… CONTINUE READING