Management of chronic traumatic encephalopathy

  title={Management of chronic traumatic encephalopathy},
  author={Robert C. Cantu and Andrew E. Budson},
  journal={Expert Review of Neurotherapeutics},
  pages={1015 - 1023}
ABSTRACT Introduction: Chronic Traumatic Encephalopathy (CTE) is a neuropathological disease defined by perivascular hyperphosphorylated tau protein depositions in a patchy distribution at the depths of cortical sulci in the brain. Presently, in living individuals, it cannot be precisely diagnosed or differentiated from other neurodegenerative diseases nor are there treatments for the underlying disease process. There are non-pharmacologic and pharmacologic treatments for the symptoms of CTE… 
5 Citations
Chronic Traumatic Encephalopathy: Update on Current Clinical Diagnosis and Management
This clinical update reviews clinical and pathologic diagnostic criteria and recommended symptomatic treatments for chronic traumatic encephalopathy, and highlights the recent advances in diagnosis using diffusor tensor imaging, functional magnetic resonance imaging, and positron emission tomography.
Secondary parkinsonism due to drugs, vascular lesions, tumors, trauma, and other insults.
Parkinsonism can be caused by chronic traumatic encephalopathy, which is a special case, since secondary insults to the brain leads to the occurrence of a neuropathologically defined disease.
Neuroimaging and advanced research techniques may lead to improved outcomes in military members suffering from traumatic brain injury
The discovery that microglia of the cerebral cortex discharged small extracellular vesicles in the injured and adjacent regions to a TBI may soon shed light on the immediate impact injury mechanisms.
The Administration of the New Pyrimidine Derivative—4-{2-[2-(3,4-Dimethoxyphenyl)-Vinyl]-6-Ethyl-4-Oxo-5-Phenyl-4H-Pyrimidine-1-Il}Benzsulfamide Restores the Activity of Brain Cells in Experimental Chronic Traumatic Encephalopathy by Maintaining Mitochondrial Function
The use of a new pyrimidine derivative contributed to the preservation of the mitochondrial respirometric function and cognitive functions in rats and high therapeutic efficacy and low systemic toxicity of the application are assumed.


Chronic Traumatic Encephalopathy: A Critical Appraisal
The existing literature on CTE was reviewed and the underlying pathophysiological mechanisms that may provide unique insights to clinicians with an in-depth understanding of the disease to aid in the diagnosis and prevention were proposed.
Chronic Traumatic Encephalopathy: Where Are We and Where Are We Going?
The CTE literature to date is reviewed, suggesting seven essential areas for future CTE research, and draws on the literature from mild traumatic brain injury and other neurodegenerative dementias, particularly when these studies provide guidance for futureCTE research.
The first NINDS/NIBIB consensus meeting to define neuropathological criteria for the diagnosis of chronic traumatic encephalopathy
Preliminary neuropathological criteria were used by 7 neuropathologists to blindly evaluate 25 cases of various tauopathies, including CTE, Alzheimer’s disease, progressive supranuclear palsy, argyrophilic grain disease, corticobasal degeneration, primary age-related tauopathy, and parkinsonism dementia complex of Guam to pave the way towards future clinical and mechanistic studies.
Clinical presentation of chronic traumatic encephalopathy
There are 2 major clinical presentations of CTE, one a behavior/mood variant and the other a cognitive variant, according to the Boston University Center for the Study of Traumatic Encephalopathy brain bank.
Chronic Traumatic Encephalopathy in Athletes: Progressive Tauopathy After Repetitive Head Injury
This work reviews 48 cases of neuropathologically verified CTE recorded in the literature and document the detailed findings of CTE in 3 professionalathletes, 1 football player and 2 boxers.
Clinical subtypes of chronic traumatic encephalopathy: literature review and proposed research diagnostic criteria for traumatic encephalopathy syndrome
Proposed research criteria for traumatic encephalopathy syndrome (TES) which consist of four variants or subtypes ( TES behavioral/mood variant, TES cognitive variant,TES mixed variant, and TES dementia) as well as classifications of ‘probable CTE’ and ‘possible Cte’ are presented.
The spectrum of disease in chronic traumatic encephalopathy.
The frequent association of chronic traumatic encephalopathy with other neurodegenerative disorders suggests that repetitive brain trauma and hyperphosphorylated tau protein deposition promote the accumulation of other abnormally aggregated proteins including TAR DNA-binding protein 43, amyloid beta protein and alpha-synuclein.
Traumatic encephalopathy: review and provisional research diagnostic criteria.
The provisional diagnostic criteria presented here are the first published criteria for this condition based upon a systematic analysis of its clinical characteristics, which is the first a step toward scientifically derived consensus criteria, which are essential to accelerate progress in the investigation of this important condition.
Chronic traumatic brain injury associated with boxing.
The mainstay of treatment of CTBI is prevention, however medications used in the treatment of Alzheimer's disease and/or parkinsonism may be utilized.
The clinical spectrum of sport-related traumatic brain injury
  • B. Jordan
  • Medicine
    Nature Reviews Neurology
  • 2013
The spectrum of acute and chronic sport-related TBI is discussed, highlighting how examination of athletes involved in high-impact sports has advanced understanding of pathology of brain injury and enabled improvements in detection and diagnosis of sport- related TBI.