Management of antiretroviral therapy for HIV infection: modelling when to change therapy.

@article{DAmato1998ManagementOA,
  title={Management of antiretroviral therapy for HIV infection: modelling when to change therapy.},
  author={Rebecca M. D'Amato and R. T. D'Aquila and Lawrence M. Wein},
  journal={Antiviral therapy},
  year={1998},
  volume={3 3},
  pages={147-58}
}
OBJECTIVE To evaluate four strategies for monitoring plasma HIV RNA levels and/or resistance genotypes to decide when to change antiretroviral therapy. The strategies include: (i) 1997 guidelines recommending a therapy switch when plasma RNA exceeds a threshold level; (ii) a viral load policy, using a fixed increase in viral load as the trigger; (iii) a genotype policy, requiring a smaller viral rebound than (ii) and detection of genotypic resistance before switching; and (iv) a proactive… CONTINUE READING
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