Management of agitation in the acute psychotic patient — Efficacy without excessive sedation
@article{Caas2007ManagementOA, title={Management of agitation in the acute psychotic patient — Efficacy without excessive sedation}, author={Fernando Ca{\~n}as}, journal={European Neuropsychopharmacology}, year={2007}, volume={17}, pages={S108-S114} }
40 Citations
The comparative efficacy of intramuscular antipsychotics for the management of acute agitation
- Psychology, MedicineAustralasian psychiatry : bulletin of Royal Australian and New Zealand College of Psychiatrists
- 2013
The comparative efficacy of the rapidly-acting IM atypical antipsychotics (olanzapine, ziprasidone and aripiprazole) is similar to that of the typical antipsychotic, haloperidol.
Are Low Doses of Antipsychotics Effective in the Management of Psychomotor Agitation? A Randomized, Rated-Blind Trial of 4 Intramuscular Interventions
- Medicine, PsychologyJournal of clinical psychopharmacology
- 2013
Low doses of haloperidol combined with midazolam can be as effective as olanzapine in reducing psychomotor agitation without increasing the risk of extrapyramidal effects.
Evidence-Based Review Of Pharmacotherapy For Acute Agitation. Part 2: Safety.
- Medicine, PsychologyThe Journal of emergency medicine
- 2018
A meta-analysis of the risk of acute extrapyramidal symptoms with intramuscular antipsychotics for the treatment of agitation.
- Medicine, PsychologyThe Journal of clinical psychiatry
- 2008
Intramuscular SGAs have a significantly lower risk of acute EPS compared to haloperidol alone, however, intramuuscular haloperodol plus promethazine has arisk of acute dystonia comparable to intramuscules SGAs, which should consider other factors in addition to the reduction of EPS.
Aripiprazole Once-Monthly in the Treatment of Acute Psychotic Episodes in Schizophrenia
- Psychology, MedicineJournal of clinical psychopharmacology
- 2017
Findings indicate that AOM 400 is efficacious across the spectrum of schizophrenia symptoms in acutely ill patients, with implications for both short-term and, by extension, long-term patient outcomes.
Consensus statement on the use of intramuscular aripiprazole for the rapid control of agitation in bipolar mania and schizophrenia
- Medicine, PsychologyCurrent medical research and opinion
- 2013
The objective of this article is to assess the available clinical data on IM aripiprazole as a treatment option for the rapid control of agitation and disturbed behaviours in these conditions and to provide a consensus statement based on the expertise of UK healthcare practitioners in acute treatment units.
Aripiprazole in patients with bipolar mania and beyond: an update of practical guidance
- Medicine, PsychologyCurrent medical research and opinion
- 2011
Clinical practice guidelines widely recommend aripiprazole as a first-line treatment for mania, and clinical trials show that aripIPrazole is well tolerated and has a long-term stabilizing potential.
Efficacy and safety of valproic acid versus haloperidol in patients with acute agitation: results of a randomized, double-blind, parallel-group trial
- Medicine, PsychologyInternational clinical psychopharmacology
- 2015
It is suggested that in the clinical practice setting of emergency psychiatry, intravenous valproate is as effective as haloperidol in reducing agitation, with a better safety profile.
Effectiveness and safety of oral olanzapine treatment transitioned from rapid-acting intramuscular olanzapine for agitation associated with schizophrenia
- Medicine, PsychologyNeuropsychiatric disease and treatment
- 2018
In the treatment of acute agitation associated with schizophrenia, RAIM could be generally transitioned to oral olanzapine without exacerbating adverse events or losing treatment effect.
A Retrospective (Post-Marketing) Case Series of Patients Receiving Intramuscular (IM) Olanzapine outside of Product Doses and Indications (Off-Label): Assessing Safety and Tolerability
- Medicine, Psychology
- 2011
Intramuscular olanzapine may be safe to use outside of product dosing and indication guidelines, and Randomized clinical trials are warranted to study such off-label use further.
References
SHOWING 1-10 OF 25 REFERENCES
Acute treatment of psychotic agitation: a randomized comparison of oral treatment with risperidone and lorazepam versus intramuscular treatment with haloperidol and lorazepam.
- Psychology, MedicineThe Journal of clinical psychiatry
- 2004
A single oral dose of risperidone plus lorazepam was as effective as parenterally administered haloperidol plus lorbizepam for the rapid control of agitation and psychosis.
A double-blind, placebo-controlled dose-response comparison of intramuscular olanzapine and haloperidol in the treatment of acute agitation in schizophrenia.
- Medicine, PsychologyArchives of general psychiatry
- 2002
Intramuscular olanzapine at a dose of 2.5 to 10.0 mg per injection exhibits a dose-response relationship in the rapid treatment of acute agitation in patients with schizophrenia and demonstrates a favorable safety profile.
Pharmacological management of agitation in emergency settings
- Psychology, MedicineEmergency medicine journal : EMJ
- 2003
Atypical antipsychotics to be as effective as the classic ones and more advantageous in many aspects, and combination treatment may be superior to the either agent alone with higher improvement rates and lower incidence of extrapyramidal side effects.
Intramuscular aripiprazole or haloperidol and transition to oral therapy in patients with agitation associated with schizophrenia: sub-analysis of a double-blind study*
- Medicine, PsychologyCurrent medical research and opinion
- 2006
Intramuscular aripiprazole is effective in patients with acute agitation associated with schizophrenia, comparable to IM haloperidol, and enables convenient transfer to oral aripIPrazole therapy.
A Double-Blind, Randomized Comparison of the Efficacy and Safety of Intramuscular Injections of Olanzapine, Lorazepam, or Placebo in Treating Acutely Agitated Patients Diagnosed With Bipolar Mania
- Psychology, MedicineJournal of clinical psychopharmacology
- 2001
Intramuscular olanzapine is a safe and effective treatment for reducing acute agitation in patients with bipolar mania and no significant differences among the three treatment groups were observed in safety measures.
Double-blind, placebo-controlled comparison of intramuscular olanzapine and intramuscular haloperidol in the treatment of acute agitation in schizophrenia.
- Medicine, PsychologyThe American journal of psychiatry
- 2001
Intramuscular olanzapine represents a rapid, effective, and safe treatment for acute agitation in schizophrenia.
Sedation in Acute and Chronic Agitation
- Psychology, MedicinePharmacotherapy
- 1996
Once remission is obtained, sedation is no longer desired and may be a barrier to optimal patient function and compliance, so strategies are used to minimize sedation, such as reducing dosages, changing administration to bedtime, or adding antidepressants or stimulants where appropriate.
Intramuscular Olanzapine and Intramuscular Haloperidol in Acute Schizophrenia: Antipsychotic Efficacy and Extrapyramidal Safety during the First 24 Hours of Treatment
- Psychology, MedicineCanadian journal of psychiatry. Revue canadienne de psychiatrie
- 2003
IM olanzapine was comparable to IM haloperidol for reducing the symptoms of acute schizophrenia during the first 24 hours of treatment, the efficacy of both being evident within 2 hours after the first injection.
The tolerability of intramuscular ziprasidone and haloperidol treatment and the transition to oral therapy
- Psychology, MedicineInternational clinical psychopharmacology
- 2004
The intramuscular (i.m.) formulation of ziprasidone offers promise as an alternative to conventional i.m. agents for the short-term management of agitated patients with psychosis and, following the transition to oral treatment, symptoms remained controlled.
Managing the first episode of schizophrenia: the role of new therapies
- Psychology, MedicineEuropean Neuropsychopharmacology
- 1996