Management of Wilms tumor: current standard of care

  title={Management of Wilms tumor: current standard of care},
  author={Geoffrey A. Sonn and Linda MD Shortliffe},
  journal={Nature Clinical Practice Urology},
Wilms tumor is the most common renal malignancy in children. In the 1930s, overall survival for children with Wilms tumor was approximately 30%. Use of multidisciplinary therapy, guided by results from multi-institutional, randomized trials, has substantially improved overall survival to about 90%. Management of Wilms tumor differs substantially between Europe and the US. In Europe, the International Society of Pediatric Oncology protocols call for management of patients with presumptive Wilms… 

Laparoscopic nephrectomy for Wilms’ tumor

It is concluded that laparoscopic nephrectomy for Wilms’ tumor is a feasible and safe procedure in a selected group of children after chemotherapy, reproduces all the steps of the open surgical approach required to treat this tumor, with the advantages of a short hospital stay and cosmetically more acceptable incisions.

Comparison of SIOP and NWTSG Protocols in Clinico-Histological Spectrum of Childhood Renal Tumors - A Tertiary Center Experience

Management of childhood renal tumors especially nephroblastoma by SIOP protocol offers distinct advantage over NWTSG treated cases by efficient reduction in viable tumor load along with demarcation of high risk cases which require further chemotherapy.

Impact of pelvic CT on staging, surveillance, and survival of pediatric patients with Wilms tumor and hepatoblastoma.

Given the low rate of pelvic involvement at relapse in children with Wilms tumor and hepatoblastoma, frequent abdominopelvic CT may not be necessary, and replacing these examinations with abdomen-only CT should be considered to decrease radiation burden to this population.

Surgery for Wilms Tumour in Children in a Tertiary Centre in Hong Kong : A 15-year Retrospective Review

This study provides updated surgical experience in the management of Wilms tumour in children in Hong Kong from January 1996 to June 2011 and achieves zero intraoperative tumour ruptured rate.

Wilms' tumour a€“ an update

A rational approach to workup of these children with Wilms' Tumour is presented focusing on imaging interpretation, with emphasis on surgical technique and an update of chemotherapeutic strategies.

Renal neoplasms of childhood.

Wilms tumor in Newborn: A Case Report and Update

A rare case of WT diagnosed at the age of only 1 month of a female newborn baby, on regular follow up for one and a half years after completion of treatment without any complications and signs of recurrence.

Indications and results of diagnostic biopsy in pediatric renal tumors: A retrospective analysis of 317 patients with critical review of SIOP guidelines

This study addresses the relevance of diagnostic biopsy of renal tumors prior to neoadjuvant chemotherapy as well as the accuracy and safety of image‐guided needle biopsy.

Retinoic acid pathway activity in wilms tumors and characterization of biological responses in vitro

In vitro testing of primary tumor cultures provided clear evidence of a potential utility of retinoids in Wilms tumor treatment based on the analysis of gene expression, proliferation, differentiation and apoptosis.

Prediction of histopathological local staging by radiological findings and differential diagnosis overview in children with nephroblastoma

H and imagistic staging are not yet sufficiently similar for successfully predict the former via imagistic means, according to a retrospective study of the medical dossiers of 22 patients that underwent surgery at the Center between 2014 and 2020.



The treatment of Wilms tumor. Results of the National Wilms Tumor Studies.

Current therapy for Wilms' tumor.

The goal of current clinical trials is to reduce therapy for children with low-risk tumors, thereby avoiding acute and long-term toxicities, and to augment therapy for patients with high-risk Wilms' tumor, including those with bilateral, anaplastic, and recurrent favorable histology tumors.

Treatment of Wilms’ tumor in children

The newly recognized histologic grading of “unfavorable” and “f favorable” prognostic types of tumor should stimulate refinement of therapy and further improvement in survival by application of more or less aggressive treatment, as appropriate.

The treatment of Wilms' tumor. Results of the national Wilms' tumor study

The National Wilms' Tumor Study, initiated in 1969, tested competing treatment strategems for patients with tumors ranging from Group (Gp) I (tumors confined to the kidney and totally removed) to Gp

Effectiveness of preoperative chemotherapy in Wilms' tumor: results of an International Society of Paediatric Oncology (SIOP) clinical trial.

  • J. LemerleP. Voûte M. Carli
  • Medicine
    Journal of clinical oncology : official journal of the American Society of Clinical Oncology
  • 1983
Preoperative chemotherapy is as good as preoperative radiotherapy in terms of prevention of tumor rupture, and 43% of an unselected population of patients with Wilms' tumor could be treated without any radiotherapy when chemotherapy had been given preoperatively.

Surgery-related factors and local recurrence of Wilms tumor in National Wilms Tumor Study 4.

This study has demonstrated that surgical rupture of the tumor must be prevented by the surgeon, because spills produce an increased risk of local relapse.

Treatment of anaplastic histology Wilms' tumor: results from the fifth National Wilms' Tumor Study.

  • J. DomeC. Cotton D. Green
  • Medicine
    Journal of clinical oncology : official journal of the American Society of Clinical Oncology
  • 2006
The prognosis for patients with stage I AH is worse than that for patientsWith stage I FH, especially those with stage III to V disease, and novel treatment strategies are needed to improve outcomes.