Management of Wilms tumor: current standard of care

@article{Sonn2008ManagementOW,
  title={Management of Wilms tumor: current standard of care},
  author={G. Sonn and L. M. Shortliffe},
  journal={Nature Clinical Practice Urology},
  year={2008},
  volume={5},
  pages={551-560}
}
Wilms tumor is the most common renal malignancy in children. In the 1930s, overall survival for children with Wilms tumor was approximately 30%. Use of multidisciplinary therapy, guided by results from multi-institutional, randomized trials, has substantially improved overall survival to about 90%. Management of Wilms tumor differs substantially between Europe and the US. In Europe, the International Society of Pediatric Oncology protocols call for management of patients with presumptive Wilms… Expand
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References

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It has been found that treatments associated with significant acute and/or long-term morbidity are not necessary for patients with stage I or II, favorable histology Wilms tumor. Expand
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Preoperative chemotherapy for Wilms' tumor results in easier operations with significantly fewer tumor ruptures during surgery and a favorable stage distribution, and partial nephrectomy in unilateral disease must be evaluated in carefully selected patients according to clear and well-defined indications. Expand
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Failure of the tumor to shrink in size with PC was significantly associated with an increase in tumor spillage and would suggest that a more cautious surgical approach be undertaken in these cases. Expand
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TLDR
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TLDR
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TLDR
This study has demonstrated that surgical rupture of the tumor must be prevented by the surgeon, because spills produce an increased risk of local relapse. Expand
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