Management of Crohn’s disease in poor responders to adalimumab

  title={Management of Crohn’s disease in poor responders to adalimumab},
  author={Nanne K. H. de Boer and Mark L{\"o}wenberg and Frank Hoentjen},
  booktitle={Clinical and experimental gastroenterology},
Anti-tumor necrosis factor therapy with adalimumab is an effective therapy for the induction and maintenance of remission in moderate to severe Crohn's disease. Although a large proportion of patients show a favorable clinical response to adalimumab, therapy failure is common. In this review, we provide a practical overview of adalimumab therapy in patients with Crohn's disease, with a specific focus on the clinical management of adalimumab failure. In the case of inadequate efficacy, a… CONTINUE READING
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