Management of Children With Sickle Cell Disease: A Comprehensive Review of the Literature

@article{Kavanagh2011ManagementOC,
  title={Management of Children With Sickle Cell Disease: A Comprehensive Review of the Literature},
  author={P. Kavanagh and P. Sprinz and Samuel R. Vinci and H. Bauchner and C. Wang},
  journal={Pediatrics},
  year={2011},
  volume={128},
  pages={e1552 - e1574}
}
OBJECTIVE: Sickle cell disease (SCD) affects 70 000 to 100 000 people in the United States, and 2000 infants are born with the disease each year. The purpose of this study was to review the quality of the literature for preventive interventions and treatment of complications for children with SCD to facilitate the use of evidence-based medicine in clinical practice and identify areas in need of additional research. METHODS: We searched the Ovid Medline database and the Cochrane Library for… Expand
Management of sickle cell disease: summary of the 2014 evidence-based report by expert panel members.
TLDR
Hydxyurea and transfusion therapy are strongly recommended for many individuals with SCD and many other recommendations are based on quality of evidence that is less than high due to the paucity of clinical trials regarding screening, management, and monitoring for individuals withSCD. Expand
Hydroxyurea can be used in children with sickle cell disease and cerebral vasculopathy for the prevention of chronic complications? A meta-analysis
TLDR
A systematic review for evaluating the impact of hydroxyurea and chronic blood transfusion in children with sickle cell disease found that the primary outcome was the occurrence of stroke and there is a lack of high-quality research in the care of children with SCD. Expand
Acute Crises and Complications of Sickle Cell Anemia Among Patients Attending a Pediatric Tertiary Unit in Kinshasa, Democratic Republic Of Congo
TLDR
In Kinshasa, the care of patients suffering from sickle cell anemia is characterized by the delayed diagnosis and low detection of organ complications compared to reports of Western countries. Expand
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TLDR
It is evident that the use of transcranial Doppler ultrasound and transfusions proved to be preventive strategies or effective treatments for the complications related to this pathology in children in Colombia. Expand
Medication Adherence Among Pediatric Patients With Sickle Cell Disease: A Systematic Review
TLDR
Moderate adherence is typical among pediatric patients with SCD and Multicomponent interventions are needed to optimally deliver life-changing medications to these children and should include routine monitoring of adherence, support to prevent mistakes, and education to improve understanding of medication risks and benefits. Expand
Study of Common Infections among Children with Sickle Cell Anaemia In Saudi Arabia
TLDR
Urinary tract infection was the most common infection in children with sickle cell disease in Kingdom of Saudi Arabia, followed by Staphylococcus species, Klebsiella pneumonia and Salmonella spcs. Expand
Multicenter COMPACT study of COMplications in Patients with sickle cell disease And utilization of iron Chelation Therapy
TLDR
Although the most commonly reported SCD complication among all patients was pain, patients who received ICT were less likely to experience pain and other complications than those who did not, highlighting the need for increased patient and provider education on the importance of comprehensive disease management. Expand
Current modalities of sickle cell disease management
Abstract Sickle cell disease (SCD) affects nearly 100,000 people in the United States of America and the sickle gene is present in approximately 8% of black Americans. Among Africans, the prevalenceExpand
What every physician should know about the national guidelines for the control and management of sickle cell disease and the parent handbook for sickle cell disease in Nigeria
Sickle cell disease (SCD) is a genetic disorder that is caused by the inheritance of HbS, which results from the substitution of valine for glutamic acid in the 6th amino acid position of theExpand
Appropriate Antibiotic Prophylaxis for Children with Sickle Cell Disease
  • 2018
This measure assesses the percentage of children between the ages of 3 months and 5 years diagnosed with sickle cell disease (SCD) who receive appropriate antibiotic prophylaxis during theExpand
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TLDR
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TLDR
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TLDR
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