Management of Cardio-Renal Syndrome and Diuretic Resistance

@article{Verbrugge2016ManagementOC,
  title={Management of Cardio-Renal Syndrome and Diuretic Resistance},
  author={Frederik H Verbrugge and Wilfried Mullens and W H Wilson Tang},
  journal={Current Treatment Options in Cardiovascular Medicine},
  year={2016},
  volume={18},
  pages={1-15}
}
Opinion statementDiuretic resistance in acute heart failure has emerged as a powerful predictor of adverse outcome, which is often independent of underlying glomerular filtration rate (GFR). Metrics of diuretic efficacy differ in their accuracy, convenience, and biological plausibility, which should be taken into account when interpreting their results. Loop diuretic efficacy depends on adequate delivery of both the pharmacological agent itself and its substrate (i.e., sodium chloride) to the… CONTINUE READING
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