1. Evaluate risk factors associated with acute ischemic stroke (AIS) and assess stroke risk after transient ischemic attack (TIA). 2. Discuss reperfusion therapy and justify the expanded time window of alteplase for AIS in appropriate populations. 3. Evaluate ongoing controversies regarding medical management of TIA/AIS. 4. Formulate primary and secondary prevention plans using risk factors for patients with TIA/AIS. 5. Delineate future neuroprotective therapies and quality improvement measures for the management of AIS.