Management and therapeutic perspectives in amyotrophic lateral sclerosis.

@article{Mathis2017ManagementAT,
  title={Management and therapeutic perspectives in amyotrophic lateral sclerosis.},
  author={St{\'e}phane Mathis and Philippe P Couratier and Adrien Julian and Jean Michel Vallat and Philippe Corcia and Gwendal Le Masson},
  journal={Expert review of neurotherapeutics},
  year={2017},
  volume={17 3},
  pages={
          263-276
        }
}
INTRODUCTION Amyotrophic lateral sclerosis (ALS) is a fatal progressive neurodegenerative disorder affecting both upper and lower motor neurons. Despite much research and effort, no clear insights into a unifying hypothesis for the pathogenesis has so far emerged for this disease. Areas covered: We review the main pathophysiological hypotheses and the potential therapeutic targets in ALS, as well as the management of these patients (in order to improve their survival and quality of life… CONTINUE READING
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