Management and monitoring of anticoagulation for children undergoing cardiopulmonary bypass in cardiac surgery.

@article{Gruenwald2010ManagementAM,
  title={Management and monitoring of anticoagulation for children undergoing cardiopulmonary bypass in cardiac surgery.},
  author={Colleen E. Gruenwald and Cedric Manlhiot and Lynn Crawford-Lean and Celeste Foreman and Leonardo R. Brand{\~a}o and Brian W McCrindle and Helen M. Holtby and Ross Stuart Richards and Helen Moriarty and Glen S. van Arsdell and Anthony K. C. Chan},
  journal={The journal of extra-corporeal technology},
  year={2010},
  volume={42 1},
  pages={9-19}
}
Cardiopulmonary bypass (CPB) creates a pro-coagulant state by causing platelet activation and inflammation leading to thrombin generation and platelet dysfunction. It is associated with severe derangements in normal homeostasis resulting in both thrombotic and hemorrhagic complications. This derangement is greater in children with congenital heart disease than in adults because of the immaturity of the coagulation system, hemodilution of coagulation factors, hyperreactive platelets, and in some… CONTINUE READING
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