Man2C1, an alpha-mannosidase, is involved in the trimming of free oligosaccharides in the cytosol.

@article{Suzuki2006Man2C1AA,
  title={Man2C1, an alpha-mannosidase, is involved in the trimming of free oligosaccharides in the cytosol.},
  author={Tadashi Suzuki and Izumi Hara and Miyako Nakano and Masaki Shigeta and Takatoshi Nakagawa and Akihiro Kondo and Yoko Funakoshi and Naoyuki Taniguchi},
  journal={The Biochemical journal},
  year={2006},
  volume={400 1},
  pages={33-41}
}
The endoplasmic-reticulum-associated degradation of misfolded (glyco)proteins ensures that only functional, correctly folded proteins exit from the endoplasmic reticulum and that misfolded ones are degraded by the ubiquitin-proteasome system. During the degradation of misfolded glycoproteins, they are deglycosylated by the PNGase (peptide:N-glycanase). The free oligosaccharides released by PNGase are known to be further catabolized by a cytosolic alpha-mannosidase, although the gene encoding… CONTINUE READING

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