Man versus beast: pharmacokinetic scaling in mammals.

  title={Man versus beast: pharmacokinetic scaling in mammals.},
  author={Joyce J Mordenti},
  journal={Journal of pharmaceutical sciences},
  volume={75 11},
Land mammals range in size from the 3-g shrew to the 3000-kg elephant. Despite this 10(6) range in weight, most land mammals have similar anatomy, physiology, biochemistry, and cellular structure. This similarity has allowed interspecies scaling of physiologic properties such as heart rate, blood flow, blood volume, organ size, and longevity. The equation that is the basis for scaling physiologic properties among mammals is the power equation Y = aWb, where Y is the physiologic variable of… CONTINUE READING

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Principles of Animal Extrapolation"

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