Man-Made Vitreous Fibers and Risk of Respiratory System Cancer: A Review of the Epidemiologic Evidence

  title={Man-Made Vitreous Fibers and Risk of Respiratory System Cancer: A Review of the Epidemiologic Evidence},
  author={I. M. Lee and Charles H. Hennekens and Dimitrios Trichopoulos and J. E. Buring},
  journal={Journal of Occupational and Environmental Medicine},
Because asbestos has been demonstrated to cause lung cancer, the issue regarding safety of other fibers, including man-made vitreous fibers (MMVF), has been raised. We reviewed the available evidence, in particular the epidemiologic data, on MMVF and the risk of respiratory system cancer. Glass fibers (especially glass wool) have been studied most extensively. Taken together, the data indicate that among those occupationally exposed, glass fibers do not appear to increase risk of respiratory… 

Respiratory cancer and exposure to man-made vitreous fibers: a systematic review.

  • D. Berrigan
  • Medicine
    American journal of industrial medicine
  • 2002
The results highlight the difficulty of assessing small increases in risk of respiratory cancer potentially caused by occupational exposure in populations with high prevalence of tobacco use.

Silica, asbestos, man-made mineral fibers, and cancer

The data suggest chrysotile does cause mesothelioma, although it may be less potent than amphibole asbestos, and recent epidemiologic studies provide little evidence for lung carcinogenicity for either glass wool or rock/slag wool.

Cytotoxicity, oxidative stress and genotoxicity induced by glass fibers on human alveolar epithelial cell line A549.

Quantitative risk assessment for a glass fiber insulation product.

The lowest nonsignificant exposures derived in this assessment are at least a factor of two higher than field exposures measured for professionals installing the R-25 fiberglass insulation product and are orders of magnitude higher than the estimated lifetime exposures for do-it-yourselfers.

The Effects of Respirable Dust Exposure on Pulmonary Function among Aircraft Repair Workers

It is suggested that occupational dust induced by repairing an aircraft has potential heath hazards, and should be controlled, and smokers and nonsmokers should be aware of these hazards.

Toxicological profile for synthetic vitreous fibers

This edition supersedes any previously released draft or final profile and is a three-volume set of recommendations for on-scene (prehospital) and hospital medical management of patients exposed during a hazardous materials incident.

Safety Assessment of Continuous Glass Filaments Used in Eclipse

Eclipse is a cigarette that produces smoke by primarily heating, rather than burning, tobacco. The Eclipse heat source assembly employs a continuous filament glass mat jacket to insulate the heat

Safety assessment of continuous glass filaments used in eclipse.

Exposure of Eclipse smokers to continuous glass filaments is extremely unlikely to occur at a level that may be construed to be of biological significance, according to the available environmental survey data.



Oral cavity and laryngeal cancers among man-made mineral fiber production workers.

The relative risk of cancers in the upper respiratory and alimentary tracts seemed to increase with the length of exposure to glass fibers and exceeded the value of 3.0 for more than 10 years of exposure.

The man-made mineral fiber European historical cohort study. Extension of the follow-up.

There was an excess of lung cancer among rock-wool/slag-wools workers employed during an early technological phase before the introduction of dust-suppressing agents, and fiber exposure, either alone on in combination with other exposures, may have contributed to the elevated risk.

Mortality among a cohort of US man-made mineral fiber workers: 1985 follow-up.

The evidence of a relationship between exposure to man-made mineral fibers and respiratory cancer appears to be somewhat weaker than in the previous update, although four malignant mesotheliomas have now been noted on death certificates.

Mortality and incidence of cancer of workers in the man made vitreous fibres producing industry: an international investigation at 13 European plants.

The result is suggestive, however, of an increased risk associated with the man made mineral fibres working environment of 30 or more years ago, and different factors including uncontrolled confounders such as smoking habits may have contributed.

Mortality study of workers in the man-made mineral fiber production industry in the United Kingdom.

The workforces of two factories in the United Kingdom have been followed up to the end of 1984 as part of the collaborative European study of the health of workers in the man-made mineral fiber industry and lung cancer mortality showed little relationship to length of employment, duration of time since first exposure, occupational classification, or level of exposure.

The health of retired fibrous glass workers.

Overall mortality was low and there was no evidence of an excess in respiratory cancer mortality, except a possible excess in chronic bronchitis, among fibrous glass workers.

Lung cancer risk and social class. The Copenhagen Male Study--17-year follow up.

It is concluded that the substantial social inequalities in lung cancer risk are only to a minor degree explained by social class differences in tobacco smoking habits.