Mammographic breast density--evidence for genetic correlations with established breast cancer risk factors.

@article{Douglas2008MammographicBD,
  title={Mammographic breast density--evidence for genetic correlations with established breast cancer risk factors.},
  author={Julie A. Douglas and Marie-H{\'e}l{\`e}ne Roy-Gagnon and Chuan Zhou and Braxton D. Mitchell and Alan R. Shuldiner and Heang-Ping Chan and Mark A. Helvie},
  journal={Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology},
  year={2008},
  volume={17 12},
  pages={3509-16}
}
Previous twin and family studies indicate that the familial aggregation of breast density is due (in part) to genetic factors. Whether these genetic influences are shared with other breast cancer risk factors, however, is not known. Using standard film-screen mammography, we screened 550 women, including 611 pairs of sisters, from the Old Order Amish population of Lancaster County, Pennsylvania. We digitized mammograms and quantified the dense and nondense areas of the breast using a computer… CONTINUE READING