Mammary tumors and serum hormones in the bitch treated with medroxyprogesterone acetate or progesterone for four years.

@article{Frank1979MammaryTA,
  title={Mammary tumors and serum hormones in the bitch treated with medroxyprogesterone acetate or progesterone for four years.},
  author={D. W. Frank and K. Kirton and T. Murchison and W. Quinlan and M. Coleman and T. Gilbertson and E. Feenstra and F. Kimball},
  journal={Fertility and sterility},
  year={1979},
  volume={31 3},
  pages={
          340-6
        }
}
After 4 years of a long-term contraceptive steroid safety study, the incidence and the histologic types of mammary dysplasia produced are shown to be similar in beagles treated with medroxyprogesterone acetate (medroxyprogesterone) or progesterone. Serum insulin, thyroid-stimulating hormone (TSH), triiodothyronine, growth hormone, prolactin, 17 beta-estradiol, progesterone, and cortisol were determined by radioimmunoassay on samples collected after 45 months of treatment. Serum growth hormone… Expand
Grwoth hormone, prolactin, and cortisol in dogs developing mammary nodules and an acromegaly-like appearance during treatment with medroxyprogesterone acetate.
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Gross and histopathologic effects of medroxyprogesterone acetate and progesterone on the mammary glands of adult beagle bitches.
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Adult beagle bitches received 0.2 to 75 mg/kg doses of medroxyprogesterone acetate once every 3 months for 1 to 1.5 years prevented the recurrence of ovarian cycles; lower doses did not. Expand
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It has been claimed that the dog is unique in its sensitivity to the mammary tumor promoting effect of progestins and that this tumorigenic effect results from progestin-induced growth hormone (GH) induction, which does not support these claims. Expand
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It was concluded that this progestagenic agent did not increase the risk of carcinoma development when administered to virgin rats at the clinical dose used for contraception, however, a 10-fold dose increase resulted in a higher tumorigenic response. Expand
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Evidence for CDB-4124 action on steroid hormone-signaling, cell cycle–regulated genes and in vivo on mammary carcinogenesis indicates that it can suppress the development of precancerous lesions and carcinogen-induced ER+ mammary tumors in rats, and may have implications for prevention and treatment of human breast cancer. Expand
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Suitability of the beagle dog as a test model for the tumorigenic potential of contraceptive steroids. "A short review".
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: Widespread use of the Beagle dog for long-term toxicity studies of hormonal contraceptives including progestagens-only, have resulted in proliferative mammary gland changes. The "tumorigenicExpand
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TLDR
No significant differences in either basal or stimulated blood prolactin concentration between the 2 groups were observed, and further research should still be done on the posssibility of MPA use being associated with increased incidence of breast tumors in humans. Expand
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In vitro determination of the presence of prolactin receptors in human breast tumor tissue may allow accurate prediction of response to endocrine ablation. Expand
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Plasma concentrations of progesterone, oestradiol, testosterone and corticosteroids have been measured by competitive protein binding methods in blood specimens taken from large groups of untreatedExpand
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TLDR
No obvious relation between DMPA use and the occurrence of breast nodules was seen and though 1 of the authors has observed 18889.8 women-years of usage of DMPA injection accompanied by oral estrogen supplement breast nodule formation has never been a patient complaint. Expand
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TLDR
Of the 60 nodules evaluated during the first 4 years of the study 50 were non-neoplastic and 10 were neoplastic, it is considered that the 1 adenocarcinoma may have been spontaneous and not a treatment-related neoplasm. Expand
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Publisher Summary This chapter describes normal target tissues including mammary gland, which contain specific receptors for hormones: (1) cytoplasmic proteins for the steroid and (2) cell-surfaceExpand
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TLDR
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TLDR
An antibody obtained by immunizing a ewe with 11α-hydroxy-progesterone-hemisuccinate conjugated to bovine serum albumin was used for the assay of progesterone in crude plasma extracts and accuracy was confirmed by the recovery of known amounts of progestersone added to plasma. Expand
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