Mammary tumor heterogeneity in the expansion of myeloid-derived suppressor cells.

@article{Donkor2009MammaryTH,
  title={Mammary tumor heterogeneity in the expansion of myeloid-derived suppressor cells.},
  author={Moses K. Donkor and Elaine Lahue and Traci A. Hoke and Laura R Shafer and Uǧur Coşkun and Joyce C. Solheim and Dumrul Gulen and John Bishay and James E Talmadge},
  journal={International immunopharmacology},
  year={2009},
  volume={9 7-8},
  pages={937-48}
}
The tumor microenvironment is heterogeneous for the expansion and infiltration by myeloid derived suppressor cells (MDSCs) which has been hypothesized to be dependent on tumor burden. We report a relationships between tumor size, MDSCs and T-cells; using four murine mammary tumors to assess tumor growth, infiltration and gene expression. Our analysis of cellular infiltration into tumors and gene expression used collagenase dissociated tumors and density gradient isolation of non-parenchymal… CONTINUE READING