Mammary stem cells: angels or demons in mammary gland?

  title={Mammary stem cells: angels or demons in mammary gland?},
  author={Xueman Chen and Qiang Liu and Erwei Song},
  booktitle={Signal Transduction and Targeted Therapy},
A highly dynamic development process exits within the epithelia of mammary gland, featuring morphogenetic variation during puberty, pregnancy, lactation, and regression. The identification of mammary stem cells (MaSCs) via lineage-tracing studies has substantiated a hierarchical organization of the mammary epithelia. A single MaSC is capable of reconstituting the entirely functional mammary gland upon orthotopic transplantation. Although different mammary cell subpopulations can be candidate… CONTINUE READING
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