Mammary stem cell number as a determinate of breast cancer risk

  title={Mammary stem cell number as a determinate of breast cancer risk},
  author={Christophe Ginestier and Max S. Wicha},
  journal={Breast cancer research : BCR},
  pages={109 - 109}
The 'cancer stem cell hypothesis' posits that cancers, including breast cancer, arise in tissue stem or progenitor cells. If this is the case, then it follows that the risk for developing breast cancer may be determined in part by the number of breast stem/progenitor cells that can serve as targets for transformation. Stem cell number may be set during critical windows of development, including in utero, adolescence, and pregnancy. The growth hormone/insulin-like growth factor-1 axis may play… CONTINUE READING
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