Mammary serine protease inhibitor (Maspin) binds directly to interferon regulatory factor 6: identification of a novel serpin partnership.

@article{Bailey2005MammarySP,
  title={Mammary serine protease inhibitor (Maspin) binds directly to interferon regulatory factor 6: identification of a novel serpin partnership.},
  author={Caleb Michael Bailey and Zhila Khalkhali-Ellis and Shinji Kondo and Naira V. Margaryan and Richard E. B. Seftor and William W. Wheaton and Sumaira Amir and Michael R. Pins and Brian C. Schutte and Mary J. C. Hendrix},
  journal={The Journal of biological chemistry},
  year={2005},
  volume={280 40},
  pages={34210-7}
}
Since its reported discovery in 1994, maspin (mammary serine protease inhibitor) has been characterized as a class II tumor suppressor by its ability to promote apoptosis and inhibit cell invasion. Maspin is highly expressed in normal mammary epithelial cells but reduced or absent in aggressive breast carcinomas. However, despite efforts to characterize the mechanism(s) by which maspin functions as a tumor suppressor, its molecular characterization has remained somewhat elusive. Therefore, in… CONTINUE READING

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