Mammary gland serotonin regulates parathyroid hormone-related protein and other bone-related signals.

Abstract

Breast cells drive bone demineralization during lactation and metastatic cancers. A shared mechanism among these physiological and pathological states is endocrine secretion of parathyroid hormone-related protein (PTHrP), which acts through osteoblasts to stimulate osteoclastic bone demineralization. The regulation of PTHrP has not been accounted for fully… (More)
DOI: 10.1152/ajpendo.00666.2011

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