Mammary gland proliferation in female rats: effects of the estrous cycle, pseudo-pregnancy and age.

@article{Hvid2012MammaryGP,
  title={Mammary gland proliferation in female rats: effects of the estrous cycle, pseudo-pregnancy and age.},
  author={Henning Hvid and Inger Thorup and Ingrid Sj{\"o}gren and Martin B. Oleksiewicz and Henrik Elvang Jensen},
  journal={Experimental and toxicologic pathology : official journal of the Gesellschaft fur Toxikologische Pathologie},
  year={2012},
  volume={64 4},
  pages={321-32}
}
Assessment of mammary gland proliferation in rats is an important endpoint in preclinical safety studies of pharmaceutical compounds. However, existing data on mammary gland proliferation in rats during the estrous cycle is conflicting, and it is unknown whether mammary gland proliferation differs between young and mature female virgin rats. Additionally, it is unclear which of the commonly applied markers of proliferating cells that is optimal for assessment of rat mammary gland proliferation… CONTINUE READING