Mammary gland development in transgenic male mice expressing human P450 aromatase.

@article{Li2002MammaryGD,
  title={Mammary gland development in transgenic male mice expressing human P450 aromatase.},
  author={Xiangdong Li and Anni M W{\"a}rri and Sari I. M{\"a}kel{\"a} and Tommi J Ahonen and Tomi K Streng and Risto S Santti and Matti Poutanen},
  journal={Endocrinology},
  year={2002},
  volume={143 10},
  pages={4074-83}
}
We recently generated a transgenic mouse strain that expresses the human aromatase gene under the ubiquitin C promoter (AROM+). We have previously shown that in these mice the serum estradiol concentration is highly elevated, whereas the testosterone concentration is decreased. In the present study we examined mammary gland development in AROM+ male mice at different ages and found that the mammary glands of AROM+ males undergo ductal and alveolar development morphologically resembling that of… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 12 extracted citations

Dysregulation of Notch and ERα signaling in AhR-/- male mice.

Proceedings of the National Academy of Sciences of the United States of America • 2016
View 5 Excerpts
Highly Influenced

Extensive effects of in vitro oocyte maturation on rhesus monkey cumulus cell transcriptome.

American journal of physiology. Endocrinology and metabolism • 2011
View 6 Excerpts
Highly Influenced

Elevated aromatase expression in osteoblasts leads to increased bone mass without systemic adverse effects.

Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research • 2009

Similar Papers

Loading similar papers…