Mammary gland development in transgenic male mice expressing human P450 aromatase.

  title={Mammary gland development in transgenic male mice expressing human P450 aromatase.},
  author={Xiangdong Li and Anni M W{\"a}rri and Sari I. M{\"a}kel{\"a} and Tommi J Ahonen and Tomi K Streng and Risto S Santti and Matti Poutanen},
  volume={143 10},
We recently generated a transgenic mouse strain that expresses the human aromatase gene under the ubiquitin C promoter (AROM+). We have previously shown that in these mice the serum estradiol concentration is highly elevated, whereas the testosterone concentration is decreased. In the present study we examined mammary gland development in AROM+ male mice at different ages and found that the mammary glands of AROM+ males undergo ductal and alveolar development morphologically resembling that of… CONTINUE READING


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