Mammary epithelial-specific disruption of the focal adhesion kinase blocks mammary tumor progression.

@article{Lahlou2007MammaryED,
  title={Mammary epithelial-specific disruption of the focal adhesion kinase blocks mammary tumor progression.},
  author={Hicham Lahlou and Virginie Sanguin-Gendreau and Dongmei Zuo and Robert Cardiff and Gordon W. McLean and Margaret C Frame and William J. Muller},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2007},
  volume={104 51},
  pages={20302-7}
}
Elevated expression and activation of the focal adhesion kinase (FAK) occurs in a large proportion of human breast cancers. Although several studies have implicated FAK as an important signaling molecule in cell culture systems, evidence supporting a role for FAK in mammary tumor progression is lacking. To directly assess the role of FAK in this process, we have used the Cre/loxP recombination system to disrupt FAK function in the mammary epithelium of a transgenic model of breast cancer. Using… CONTINUE READING

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