Mammary epithelial-specific disruption of focal adhesion kinase retards tumor formation and metastasis in a transgenic mouse model of human breast cancer.

@article{Provenzano2008MammaryED,
  title={Mammary epithelial-specific disruption of focal adhesion kinase retards tumor formation and metastasis in a transgenic mouse model of human breast cancer.},
  author={Paolo P. Provenzano and David R. Inman and Kevin W. Eliceiri and Hilary E. Beggs and Patricia J. Keely},
  journal={The American journal of pathology},
  year={2008},
  volume={173 5},
  pages={1551-65}
}
Focal adhesion kinase (FAK) is a central regulator of the focal adhesion, influencing cell proliferation, survival, and migration. Despite evidence demonstrating FAK overexpression in human cancer, its role in tumor initiation and progression is not well understood. Using Cre/LoxP technology to specifically knockout FAK in the mammary epithelium, we showed that FAK is not required for tumor initiation but is required for tumor progression. The mechanistic underpinnings of these results… CONTINUE READING

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