Mammary epithelial cells undergo secretory differentiation in cycling virgins but require pregnancy for the establishment of terminal differentiation.

@article{Robinson1995MammaryEC,
  title={Mammary epithelial cells undergo secretory differentiation in cycling virgins but require pregnancy for the establishment of terminal differentiation.},
  author={Gertraud W. Robinson and Robert A McKnight and Gilbert H Smith and Lothar Hennighausen},
  journal={Development},
  year={1995},
  volume={121 7},
  pages={2079-90}
}
Postnatal development of the mammary gland begins during puberty with ductal proliferation and is completed at delivery with the appearance of secretory alveolar structures. Using endogenous milk protein genes and a WAP-lacZ reporter transgene, we show that the differentiation of alveolar cells is initiated in virgin mice in estrus in a limited number of cells. With the onset of pregnancy, the number of expressing cells and the cellular expression levels increase until full activity is reached… CONTINUE READING
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Regulation of human protein C gene expression by the mouse WAP promoter

  • R. K. Paleyanda, Zhang, D.-W, L. Hennighausen, R. A. McKnight, H. Lubon
  • Transgenic Research
  • 1994
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