Mammary ductal elongation and myoepithelial migration are regulated by the composition of the extracellular matrix.

@article{NguyenNgoc2013MammaryDE,
  title={Mammary ductal elongation and myoepithelial migration are regulated by the composition of the extracellular matrix.},
  author={K-V Nguyen-Ngoc and Andrew J Ewald},
  journal={Journal of microscopy},
  year={2013},
  volume={251 3},
  pages={212-23}
}
Mammary branching morphogenesis occurs over a period of weeks deep inside an adipocyte-rich stroma. The adipocytes contain light-scattering lipid droplets that limit the depth of penetration of visible light. Organotypic culture methods were developed to enable high-resolution optical monitoring of branching morphogenesis ex vivo. A challenge has been to identify the best culture conditions to model specific developmental events. We recently demonstrated that collagen I induces protrusive… CONTINUE READING