Mammary collective cell migration involves transient loss of epithelial features and individual cell migration within the epithelium.

@article{Ewald2012MammaryCC,
  title={Mammary collective cell migration involves transient loss of epithelial features and individual cell migration within the epithelium.},
  author={Andrew J Ewald and Robert H{\"u}bner and Hildur Palsdottir and Jessie Lee and Melissa J. Perez and Danielle M Jorgens and Andrew N. Tauscher and Kevin J. Cheung and Zena Werb and Manfred Auer},
  journal={Journal of cell science},
  year={2012},
  volume={125 Pt 11},
  pages={2638-54}
}
Normal mammary morphogenesis involves transitions between simple and multilayered epithelial organizations. We used electron microscopy and molecular markers to determine whether intercellular junctions and apico-basal polarity were maintained in the multilayered epithelium. We found that multilayered elongating ducts had polarized apical and basal tissue surfaces both in three-dimensional culture and in vivo. However, individual cells were only polarized on surfaces in contact with the lumen… CONTINUE READING

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We conclude that mammary epithelial morphogenesis involves a reversible , spatially limited , reduction in polarity and intercellular junctions and active individualistic cell migration .
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