Corpus ID: 21886170

Mammary carcinoma cells over-expressing tissue inhibitor of metalloproteinases-1 show enhanced vascular endothelial growth factor expression.

  title={Mammary carcinoma cells over-expressing tissue inhibitor of metalloproteinases-1 show enhanced vascular endothelial growth factor expression.},
  author={H. Yoshiji and S. Harris and E. R{\'a}s{\'o} and D. Gomez and C. K. Lindsay and M. Shibuya and C. C. Sinha and U. Thorgeirsson},
  journal={International journal of cancer},
  volume={75 1},
The tissue inhibitor of metalloproteinases-1 (TIMP-1) has at least 2 independent functions, i.e., regulation of matrix metalloproteinases and erythroid-potentiating activity. We investigated the effects of TIMP-1 over-expression on tumor growth, using cloned lines derived from a TIMP-1-transfected rat breast carcinoma cell line. The in vitro growth rate of the TIMP-1-transfected clones was indistinguishable from that of the control. In contrast, the highest TIMP-1-producing clone (159.0 ng/ml… Expand
Tissue Inhibitor of Metalloproteinases-1 Stimulates Gene Expression in MDA-MB-435 Human Breast Cancer Cells by Means of its Ability to Inhibit Metalloproteinases
A complex action of TIMP-1 on cancer cells mediated by constitutively active cell surface metalloproteinases that release factors regulating cell signaling pathways may account for the paradoxical observation that elevated levels of TIMp-1 in tumors can correlate with an adverse prognosis. Expand
TIMP-1 Overexpression in Lung Carcinoma Enhances Tumor Kinetics and Angiogenesis in Brain Metastasis
Results indicate tumor-promoting functions of TIMP-1 through alterations in angiogenesis, increased tumorigenicity, and invasive behavior are indicated. Expand
Long-term exposure to elevated levels of circulating TIMP-1 but not mammary TIMP-1 suppresses growth of mammary carcinomas in transgenic mice.
It is shown that circulating TIMP-1, but not mammary-derived TIMP1, has growth suppressive effects on DMBA and MT-induced mammary carcinomas. Expand
TIMP-1 Alters Susceptibility to Carcinogenesis
The combined implications of these studies suggest that TIMP-1 is an important contributor to epithelial neoplastic progression and supports the concept that TIMp-1 exerts differential regulation on tissues in a stage-dependent manner. Expand
Overexpression of TIMP-1 and Sensitivity to Topoisomerase Inhibitors in Glioblastoma Cell Lines
The present study suggests that TIMP-1 overexpression reduces the effect of TOP inhibitors in glioblastoma, and appears to reduce spheroid growth, but did not influence invasion. Expand
Tissue inhibitor of metalloproteinases‐1 (TIMP‐1) inhibits tumor growth and angiogenesis in the TIMP‐1 transgenic mouse model
Results suggested that the ectopically overexpressed TIMP‐1 inhibited the tumor growth by angiogenesis suppression, and this effect was not due to cytotoxicity. Expand
Recombinant TIMP-1-GPI inhibits growth of fibrosarcoma and enhances tumor sensitivity to doxorubicin
Intraoperative peritumoral application of GPI-anchored TIMP-1 as an adjuvant to surgery may help maintain tumor control by targeting microscopic residual fibrosarcoma cells and increasing their sensitivity to chemotherapy. Expand
The tissue inhibitor of metalloproteinases 1 increases the clonogenic efficiency of human hematopoietic progenitor cells through CD63/PI3K/Akt signaling.
Findings indicate that rhTIMP-1 promotes clonogenic expansion and survival in human progenitors via the activation of the CD63/PI3K/pAkt signaling pathway, suggesting that TIMP- 1 might be a key player in the network of proinflammatory factors modulating HSPC functions. Expand
Differential expression and localization of TIMP-1 and TIMP-4 in human gliomas
R reverse transcription-PCR analyses of total RNA from surgical tumour specimens revealed unique expression patterns for the 4 members of the TIMP family, with TIMP-1 and -4 showing positive and negative correlations, respectively, with glioma malignancy. Expand
TIMP-1 overexpression promotes tumorigenesis of MDA-MB-231 breast cancer cells and alters expression of a subset of cancer promoting genes in vivo distinct from those observed in vitro
The combined observations suggest that the effects of TIMP-1 differ significantly in a 2-D environment compared to the 3-D environments and that TIMp-1 stimulates tumor growth. Expand